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Vitamin B12 Deficiency Symptoms

January 25, 2023 - Bhoomika Singh, Webmedy Team

Updated Version - January 2, 2025


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Vitamin B12 is an essential nutrient that your body needs for processes such as DNA synthesis, energy production, and brain and central nervous system function. It plays an important role in the formation of red blood cells. It plays an important role in the metabolism of every cell in the body as well as in DNA synthesis. Vitamin B12 deficiency can cause anemia, fatigue, nerve damage, and other problems.

Causes of Vitamin B12 Deficiency

  • Malabsorption

    Malabsorption of vitamin B12 can be caused by many reasons, such as anemia in autoimmune gastritis, surgical removal of the stomach, chronic inflammation of the pancreas, intestinal parasites, genetic disorders, and the use of certain drugs.

    Because the ability to absorb B12 from food decreases with age, deficiency is more common in older adults. However, B12 deficiency can also occur in children and young adults.

  • Inadequate Diet

    Vitamin B12 deficiency can be caused by malnutrition or an inadequate diet, such as a vegetarian diet.

Symptoms of Vitamin B12 Deficiency

Vitamin B12 is an essential nutrient needed for proper brain and nervous system function and for the formation of red blood cells. Vitamin B12 deficiency can cause a variety of symptoms.

Let us look at the 5 main symptoms of Vitamin B12 deficiency.

  • Fatigue and Weakness

    Vitamin B12 is essential for the production of red blood cells, which are responsible for carrying oxygen from the lungs to the tissues of the body. When the body becomes deficient in Vitamin B12, it can lead to a decrease in the number of red blood cells, resulting in a condition called anemia.

    Anemia can cause a number of symptoms, including fatigue, weakness, shortness of breath and dizziness. Oxygen is necessary for the production of energy in the body, and without it, the cells and tissues of the body cannot function properly. Shortness of breath occurs because the body does not get enough oxygen due to a decrease in the number of red blood cells. Dizziness can also occur due to lack of oxygen in the brain.

    Vitamin B12 is involved in the metabolism of carbohydrates, fats and proteins, which are the body's primary sources of energy. Without enough vitamin B12, the body's ability to produce energy from these nutrients is impaired, leading to fatigue and weakness.

  • Neurological Problems

    Studies have shown that vitamin B12 deficiency can cause changes in the structure and function of the brain, which can lead to cognitive decline and memory loss. Vitamin B12 plays an important role in the production of myelin, a fatty substance that forms a protective sheath around nerve fibers in the brain. Without enough vitamin B12, the myelin sheath can become damaged, causing problems with nerve impulse transmission and cognitive function.

    Vitamin B12 plays a role in the synthesis of neurotransmitters such as serotonin and dopamine that are important for mood, memory and cognitive function. Without enough vitamin B12, production of these neurotransmitters can be disrupted, which can lead to cognitive decline and memory loss.

    Nerve damage caused by vitamin B12 deficiency can cause numbness or tingling in the hands and feet. Vitamin B12 deficiency can cause difficulty walking and balance problems.

  • Mouth and Tongue Problems

    Vitamin B12 is essential for the proper functioning of cells in the mouth and digestive system. When there is a deficiency of vitamin B12 in the body, it can lead to a condition called glossitis, which is an inflammation of the tongue. Glossitis causes the tongue to become swollen, red and sore, making it difficult and painful to eat or speak.

    Vitamin B12 deficiency can also lead to cold sores or canker sores, which are small, painful sores that develop inside the mouth. These sores can occur on the tongue, lips, gums or inside of the cheeks. Vitamin B12 deficiency can weaken the immune system, making it easier for bacteria to infect the mouth and cause sores.

  • Digestive Problems

    Vitamin B12 plays an important role in the proper functioning of the digestive system, including nutrient absorption and regulation of bowel movements. When there is a deficiency of Vitamin B12 in the body, it can lead to a change in bowel habits. Research has shown that vitamin B12 deficiency can lead to gastrointestinal symptoms, such as constipation, diarrhea, bloating and loss of appetite. These symptoms may be related to a disruption of normal digestive processes, which can affect the movement of food through the intestines.

    Vitamin B12 deficiency can lead to a condition called bacterial overgrowth in the small intestine. This occurs when there is an overgrowth of bacteria in the small intestine, which can lead to gastrointestinal symptoms, such as diarrhea, bloating and abdominal pain.

  • Eyesight Problems

    Vitamin B12 is important for proper functioning of the nervous system, including the nerves that control vision. When there is a deficiency of vitamin B12 in the body, it can cause neurological symptoms including vision problems. Studies have shown that vitamin B12 deficiency can cause changes in the optic nerve, which is responsible for transmitting visual information from the eyes to the brain. This can result in vision problems, such as blurred vision, double vision, or reduced vision.

Summary

Vitamin B12 supplements can interact with certain medications, such as metformin used for diabetes, proton pump inhibitors used for acid reflux, and some antibiotics. Taking more than the recommended dose of vitamin B12 can cause side effects such as acne, diarrhea and upset stomach. While vitamin B12 is generally considered safe, long-term use of high doses can cause skin reactions and problems such as anemia.

Helpful Information

What are the symptoms of vitamin B12 deficiency?

Symptoms of vitamin B12 deficiency can be subtle and vary from person to person. They can include fatigue, weakness, constipation, loss of appetite, weight loss, and megaloblastic anemia. Neurological problems, such as numbness and tingling in the hands and feet, can also occur. Other symptoms include balance problems, depression, confusion, poor memory, and soreness of the mouth or tongue.

How long does it take for B12 deficiency symptoms to appear?

How quickly B12 deficiency symptoms appear can depend on a variety of factors, including the individual's diet, age, and overall health. Generally, symptoms may appear within a few months to a year after the body's stores of vitamin B12 start to run low. However, it can take years for symptoms to appear in some cases, particularly if the deficiency is due to a gradual decrease in the ability to absorb B12.

Can vitamin B12 deficiency cause fatigue?

Yes, fatigue is one of the most common symptoms of vitamin B12 deficiency. This is because the body needs B12 to make red blood cells, which carry oxygen throughout the body. Without enough oxygen in the cells, a person can feel tired and weak.

What mental symptoms can a vitamin B12 deficiency cause?

A deficiency in vitamin B12 can cause a range of mental symptoms, including depression, mood swings, confusion, and memory loss. In severe cases, it can lead to dementia. It's thought that these effects are due to the role of vitamin B12 in brain function and the synthesis of neurotransmitters.

Is hair loss a symptom of vitamin B12 deficiency?

While it's less common, vitamin B12 deficiency can contribute to hair loss. B12 helps in the production of red blood cells, which carry oxygen to all cells in the body, including hair follicles. Without adequate oxygen, hair follicles may not be able to grow new hair effectively.

Can a vitamin B12 deficiency cause skin problems?

Yes, vitamin B12 deficiency can lead to skin problems. These can include hyperpigmentation (dark, discolored patches of skin), vitiligo (loss of skin color in blotches), hair changes, and angular stomatitis (cracks at the corners of the mouth).

Can vitamin B12 deficiency cause anemia?

Yes, one of the most common effects of vitamin B12 deficiency is a type of anemia called megaloblastic anemia. This is characterized by the production of larger-than-normal red blood cells that don't function properly, leading to less oxygen being transported to the body's cells.

Is shortness of breath a symptom of vitamin B12 deficiency?

Yes, shortness of breath can be a symptom of vitamin B12 deficiency. This is usually related to anemia caused by the deficiency, which results in the body's cells not receiving enough oxygen.

Can vitamin B12 deficiency lead to weight gain or loss?

Vitamin B12 deficiency can sometimes lead to weight loss due to loss of appetite. However, it is less likely to cause weight gain. Weight changes are generally not the primary symptoms of B12 deficiency and could be indicative of other health issues as well.

How does vitamin B12 deficiency affect the digestive system?

Vitamin B12 deficiency can affect the digestive system by causing symptoms such as nausea, loss of appetite, constipation, and weight loss. It can also lead to a swollen and inflamed tongue and mouth ulcers.

Can vitamin B12 deficiency cause neurological problems?

Yes, vitamin B12 deficiency can lead to neurological problems. These can include numbness and tingling in the hands and feet, balance problems, and depression. Severe, prolonged deficiency can even lead to irreversible damage to the nervous system.

Is blurred vision a symptom of vitamin B12 deficiency?

Blurred vision can occur in vitamin B12 deficiency due to optic neuropathy, a condition where the optic nerve that leads to the eye is damaged. This is a less common symptom but requires immediate attention to prevent long-term damage to vision.

Can vitamin B12 deficiency cause muscle weakness?

Yes, muscle weakness can be a symptom of vitamin B12 deficiency. This is usually due to anemia or low oxygen levels in the cells, which can make it difficult for muscles to function optimally.

Is difficulty in walking a symptom of vitamin B12 deficiency?

Yes, difficulty in walking can be a symptom of severe vitamin B12 deficiency. This is often due to the neurological impact of the deficiency, which can affect balance and coordination.

Can vitamin B12 deficiency cause mood changes?

Yes, mood changes, including depression and irritability, can be symptoms of vitamin B12 deficiency. Vitamin B12 plays a role in producing brain chemicals that affect mood and other brain functions.

Can a lack of vitamin B12 cause tongue problems?

Yes, a lack of vitamin B12 can lead to a condition known as glossitis, which causes a swollen, inflamed, and sometimes painful tongue. This can also lead to changes in the way a person talks and eats.

Is numbness or tingling a symptom of vitamin B12 deficiency?

Yes, numbness or tingling in the hands and feet, also known as peripheral neuropathy, can be a symptom of vitamin B12 deficiency. This is due to the role B12 plays in the healthy functioning of the nervous system.

Can a vitamin B12 deficiency cause memory problems?

Yes, memory problems, confusion, and even dementia can be symptoms of severe vitamin B12 deficiency. This is due to the crucial role B12 plays in brain function and the formation of red blood cells, which deliver oxygen to the brain.

How does vitamin B12 deficiency affect heart health?

Vitamin B12 deficiency can indirectly affect heart health by increasing the levels of homocysteine, an amino acid in your blood. High levels of homocysteine have been linked to an increased risk of heart disease.

Can vitamin B12 deficiency lead to a weakened immune system?

While vitamin B12 is essential for healthy nerve tissue, brain function, and the production of red blood cells, its role in the immune system is less clear. However, as vitamin B12 is involved in cellular function and replication, a deficiency might lead to decreased immune function. More research is needed in this area.

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